We have an exciting opportunity to undertake research towards a MSc qualification. The project will create new carbohydrate-derived materials for bio-assay testing as medicinal compounds. It builds on our prior work (Org. Lett. 2014, 16, 4543; Org. Biomol. Chem. 2012, 10, 5636). This research programme will expose the successful candidate to various synthesis techniques. There is also the opportunity to work alongside our biology collaborators in some of the bioassay studies.
Candidates who are motivated, self-starters, have an excellent academic record and who are keen to make a difference to the science and technology utilised by a major contributor to the New Zealand manufacturing sector are urged to apply.
The chemical methodology adopted will utilize a variety of modern techniques. These include the use of self-immolative linkers, chemoselective conjugation methods including strain promoted alkyne-azide cycloaddition (SPAAC), utilization of a PEE-G endrimer scaffold and solid phase peptide synthesis (SPPS). The conceptual design incorporates multiple copies or either 1 or more tumour-associated antigens (TAAs) covalently attached to a dendrimer scaffold that also includes the covalent attachment of an immune adjuvant (Figure 1). The project will assess if increased antigen-loading is beneficial for vaccine efficacy by comparing dendrimer generations (G1-G4) etc.
This PhD project will focus on taking this dendrimer scaffold and elaborating it to demonstrate proof-of-concept examples of how this scaffold can be used as a drug. It will involve the development of synthetic chemical methodology to give high purity, well defined products. HPLC and LCMS will be used to interrogate products for side reactions and the synthetic methodology refined to minimise these. The student will therefore be exposed to a range of synthetic and analytical techniques, working alongside a team of professional scientists. The products will be tested in biological assays by collaborators and there will be the opportunity for the successful candidate to participate in performing some of
The main purpose of the Scholarship is to assist international students who are citizens of Colombo Plan member countries, to study undergraduate or postgraduate engineering programmes at The University of Auckland.
Institutions can apply to host a specific Specialist from the Council for International Exchange of Scholars' (CIES) Fulbright Specialist Roster or make an open application to have a suitable Specialist assigned to meet their needs.